Capabilities | Biotechnology & Computational Analysis

Biotechnology and Computational Analysis
Computational models of human anatomy and physiology enable in-depth understanding of how chemicals, biologics and other hazards affect the human body.

ARA’s strengths in Biotechnology and Computational Analysis are exemplified by a portfolio of experience and expertise in the areas of biotechnology research and development, aerosol science, bio-surveillance, and in the use of modeling to predict human effects from chemical, biological, radiological and nuclear (CBRN) environments.

The application of these methods in combination with emerging technologies enables ARA to stay at the forefront of detection, prediction, analysis and protection from potential hazards to human health and safety.

 

  • Bio-Surveillance Partially Observed Epidemics (DTRA)

    Health and Human Effects Modeling for CBRN: develop high-fidelity, physiologically-based health effects models for the Defense Threat Reduction Agency

    • Advances in CBR casualty estimation and spread of contagious disease
    • R&D on medical planning tools, accounting for medical countermeasures and resource limitations
    • Enhancement of military consequence assessment and management tools and military support of civilian CBRN incidents
  • Modeling Medical Countermeasures vs CBR Agents (Gryphon Scientific)

    Modeling Medical Countermeasures vs CBR Agents: address gaps in existing models of chemical and radiological countermeasures by ARA for Gryphon Scientific

    • Review existing models of chemical and radiological exposure and medical countermeasures when available to identify knowledge and capability gaps
    • Develop medical countermeasure models for CBR agents, which evaluate efficacy of different treatments and treatment regimes
  • City Modeling for Urban IND Response Planning (FEMA)

    Urban IND Modeling and Response Planning: analysis of radiation, blast and thermal effects of an urban detonation for the Federal Emergency Management Agency

    • Model the effects of urban terrain on blast, thermal and radiation environments from select Improvised nuclear device scenarios
    • Assess casualty and injury estimation resulting from these environments
    • Evaluate public health and medical facility impacts for emergency response planning
  • Military Design and Performance (ARI)

    Military Design and Performance: define the problem space prior to detailed planning through critical thinking and discourse by ARA for the US Army Research Institute

    • Identify critical factors that impede successful integration of design into military operations
    • Capture design expertise, lessons learned and requirements in information needs of commanders and planners
    • Develop indicators for assessing the impact of design on critical elements of organizational performance
  • Liver Microsphere Distribution Analysis (LCRF)

    Liver Microsphere Distribution Analysis: visualization software and input files for use in research and education by ARA for the Liver Cancer Research Fund

    • Software development for semi-automatic microsphere pixel/location detection from high-res clinical histology images
    • Semi-automatic quantification of clustering and distribution of microspheres and visualization to display contour maps
    • Visualization software provides input files from dataset analysis for use in research and education
  • Decontamination and Reuse of Filtering Facepiece Respirators (FFR) in the Event of a Shortage Caused by Pandemic Influenza

    Device for Decontaminating Filtering Facepiece Respirator: a chamber for applying warm moist heat (WMH) to FFRs prior to decontamination using Ultraviolet Germicidal Irradiation (UVGI).

    • Pandemic influenza preparedness research
    • Respiratory protection research
    • Test standard development
  • Health & Human Effects Modeling for CBRN (DTRA)

    Health and Human Effects Modeling for CBRN: develop high-fidelity, physiologically-based health effects models for the Defense Threat Reduction Agency.

    • Advances in CBR casualty estimation and spread of contagious disease
    • R&D on medical planning tools, accounting for medical countermeasures and resource limitations
    • Enhancement of military consequence assessment and management tools and military support of civilian CBRN incidents
  • Human Survivability from Radiological and Nuclear Weapons (DTRA)

    Human Survivability from Radiological and Nuclear Weapons: research and development on physiologically-based human response models and calculation and analysis of nuclear weapons environments for the Defense Threat Reduction Agency

    • Develop physiologically-based human response models to improve casualty estimation and guidance on patient outcomes
    • Analyze calculations of nuclear weapons environments to support consequence assessment and forensics applications
    • Develop fast-running operational tools
  • Develop a dosimetry model to study the health impact of exposure to fibers in humans, rats and mice for the Environmental Protection Agency Develop a dosimetry model to study the health impact of exposure to fibers in humans, rats and mice for the Environmental Protection Agency

    Develop a dosimetry model to study the health impact of exposure to fibers in humans, rats and mice for the Environmental Protection Agency

    • Determine inhalability of fibers for humans, rats and mice
    • Assess nasal and oral deposition efficiency of fibers in humans, rats and mice
    • Develop a complete respiratory model of fiber deposition in humans, rats and mice
  • 3-D imaging & Computer Modeling of the Respiratory Tract (NIH)

    Three-Dimensional Imaging and Computer Modeling of the Respiratory Tract: National Institutes of Health grant to modify MPPD to interface with the PNNL CFD-based, site-specific deposition model

    • Modify MPPD to communicate with the site-specific deposition model of PNNL
    • Provide an estimate of particle concentration and flow rate at the interface of the two models during inhalation and exhalation
    • Create a user-friendly software application based on the deposition model
  • Mouse Dosimetry Modeling & Risk Assessment (NIH) Mouse Dosimetry Modeling & Risk Assessment (NIH)

    National Institutes of Health grant to develop a dosimetry model for use by the scientific community and risk assessors to predict the fraction of inhaled nanomaterials

    • Characterize the complete respiratory structure of the mouse
    • Develop a mechanistic model of nanoparticle transport and deposition in the lungs of mice
    • Create a user-friendly software application based on the deposition model
  • Modeling of Nanotube Deposition (NIOSH)

    Develop a deposition model for carbon nanotubes for the National Institute of Occupational Safety & Health

    • Determine equivalent diameters for irregularly-shaped nanotubes
    • Develop models of nanotube deposition in the head airways
    • Develop models of nanotube deposition in the head airways
  • Bioearosol Dispersing System (Droplet Chamber)

    Bioearosol Dispersing System (Droplet Chamber)

    • Contaminated surfaces play a significant role in disease transmission, and proper study of fomites contaminated with influenza require aerosol-based contamination methods
    • Develop two aerosol deposition methods: droplet nuclei and large droplet
    • Results validated and approved as ASTM standards
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