Modeling Medical Countermeasures vs CBR Agents: address gaps in existing models of chemical and radiological countermeasures by ARA for Gryphon Scientific

• Review existing models of chemical and radiological exposure and medical countermeasures when available to identify knowledge and capability gaps
• Develop medical countermeasure models for CBR agents, which evaluate efficacy of different treatments and treatment regimes

Urban IND Modeling and Response Planning: analysis of radiation, blast and thermal effects of an urban detonation for the Federal Emergency Management Agency

• Model the effects of urban terrain on blast, thermal and radiation environments from select Improvised nuclear device scenarios
• Assess casualty and injury estimation resulting from these environments
• Evaluate public health and medical facility impacts for emergency response planning

Military Design and Performance: define the problem space prior to detailed planning through critical thinking and discourse by ARA for the US Army Research Institute

• Identify critical factors that impede successful integration of design into military operations
• Capture design expertise, lessons learned and requirements in information needs of commanders and planners
• Develop indicators for assessing the impact of design on critical elements of organizational performance

Liver Microsphere Distribution Analysis: visualization software and input files for use in research and education by ARA for the Liver Cancer Research Fund

• Software development for semi-automatic microsphere pixel/location detection from high-res clinical histology images
• Semi-automatic quantification of clustering and distribution of microspheres and visualization to display contour maps
• Visualization software provides input files from dataset analysis for use in research and education

Device for Decontaminating Filtering Facepiece Respirator: a chamber for applying warm moist heat (WMH) to FFRs prior to decontamination using Ultraviolet Germicidal Irradiation (UVGI).

• Pandemic influenza preparedness research
• Respiratory protection research
• Test standard development

Health and Human Effects Modeling for CBRN: develop high-fidelity, physiologically-based health effects models for the Defense Threat Reduction Agency.

• Advances in CBR casualty estimation and spread of contagious disease
• R&D on medical planning tools, accounting for medical countermeasures and resource limitations
• Enhancement of military consequence assessment and management tools and military support of civilian CBRN incidents

Human Survivability from Radiological and Nuclear Weapons: research and development on physiologically-based human response models and calculation and analysis of nuclear weapons environments for the Defense Threat Reduction Agency

• Develop physiologically-based human response models to improve casualty estimation and guidance on patient outcomes
• Analyze calculations of nuclear weapons environments to support consequence assessment and forensics applications
• Develop fast-running operational tools

Develop a dosimetry model to study the health impact of exposure to fibers in humans, rats and mice for the Environmental Protection Agency

• Determine inhalability of fibers for humans, rats and mice
• Assess nasal and oral deposition efficiency of fibers in humans, rats and mice
• Develop a complete respiratory model of fiber deposition in humans, rats and mice

Three-Dimensional Imaging and Computer Modeling of the Respiratory Tract: National Institutes of Health grant to modify MPPD to interface with the PNNL CFD-based, site-specific deposition model

• Modify MPPD to communicate with the site-specific deposition model of PNNL
• Provide an estimate of particle concentration and flow rate at the interface of the two models during inhalation and exhalation
• Create a user-friendly software application based on the deposition model

National Institutes of Health grant to develop a dosimetry model for use by the scientific community and risk assessors to predict the fraction of inhaled nanomaterials

• Characterize the complete respiratory structure of the mouse
• Develop a mechanistic model of nanoparticle transport and deposition in the lungs of mice
• Create a user-friendly software application based on the deposition model

Develop a deposition model for carbon nanotubes for the National Institute of Occupational Safety & Health

• Determine equivalent diameters for irregularly-shaped nanotubes
• Develop models of nanotube deposition in the head airways
• Develop models of nanotube deposition in the head airways

Bioearosol Dispersing System (Droplet Chamber)

• Contaminated surfaces play a significant role in disease transmission, and proper study of fomites contaminated with influenza require aerosol-based contamination methods
• Develop two aerosol deposition methods: droplet nuclei and large droplet
• Results validated and approved as ASTM standards